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CoQ10 – 8X

$56.95 $59.95 / month

CoQ10-8X is Natural Medicine Formulas’ proprietary, crystal-free CoQ10 formula that offers unparalleled absorption and bioavailability. This formulation has been shown in clinical trials to be over eight times more absorbable than powdered CoQ10 and more than twice as bioavailable as other oil-based or so-called “nano”-dispersed formulas on the market. The proprietary multilipid carrier employed in CoQ10-8X is unmatched for optimal utilization in the support of cardiovascular and energy-based health needs.*

Benefits:

    • Innovative, Soy-Free, Five-Lipid Blend for Enhanced Absorption*
    • Support Natural Energy Generation and Mitochondrial Function*
    • Support Plasma/Tissue CoQ10 Levels*
    • Support Health/Functioning of the Cardiovascular System*
    • Support Neuromuscular and Central Nervous System Health*
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Supplement Facts

DIRECTIONS: Take one softgel one to two times daily, or as directed by your healthcare practitioner. Optimal results may be achieved by consuming with meals that contain fat.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

CoQ10 – 8X is Natural Medicine Formulas® proprietary, micro-emulsified, 50 mg CoQ10 for convenient dosing. The formula offers unparalleled absorption and bioavailability. CoQ10 – 8X has been shown in clinical trials to be over eight times more absorbable than powdered CoQ10 and more than twice as bioavailable as oil-based or so-called “nano”-dispersed formulas on the market. CoQ10 – 8X ’s proprietary multi-lipid carrier is a formulation that is unmatched for optimal utilization in the support of cardiovascular and energy-based health needs.*

STORAGE: Keep closed in a cool, dry place out of reach of children. Variations in temperature may cloud the softgels. This does not affect the formula’s efficacy or safety. Do not refrigerate.

DOES NOT CONTAIN: Wheat, gluten, corn, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.

Description

Discussion
Coenzyme Q10 (CoQ10) is a fat-soluble substance that plays a major role in energy production and antioxidant protection in the body. It is found in the body primarily in its interchangeable ubiquinone and ubiquinol forms. In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis, and neurological and cardiovascular health.[1,2] Levels of CoQ10 in the body can be affected by a number of factors. Dietary contribution of CoQ10 is minimal and serum levels tend to decline with age or can be reduced due to druginduced nutrient depletion.*[3-5]

Synthesis of CoQ10 in the body is regulated by the enzyme HMG-CoA reductase. A variety of factors can inhibit HMG-CoA reductase and hinder CoQ10 production and availability, resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event of reduced production, or drug-induced nutrient depletion, physicians recommend supplementation with CoQ10 to help maintain normal levels in the body.[6,7] Supplementation with CoQ10 has been found to promote favorable outcomes for a targeted group of patients[8] and to improve quality of life, energy levels, neurological health maintenance, exercise tolerance, and muscle comfort for a wide range of individuals.[1,9] A research study utilizing functional intracellular assay (FIA) suggested that CoQ10 may be a potential peripheral biomarker of antioxidant status in neurological health maintenance.*[10]

CoQ10-8X contains a unique, crystal-free, highly bioavailable form of ubiquinone and represent a new generation of CoQ10 supplementation. This soy-free formulation contains five lipids that help dissolve CoQ10 crystals into single molecules. This process helps stabilize the formula to prevent recrystallization and facilitates passive diffusion to enhance absorption. Earlier generation supplements were poorly absorbed (0.6-1.0%), pure crystalline (powdered) forms of CoQ10, which served as the industry standard from the mid-1970s to the mid-1990s. A variety of forms and delivery systems offered somewhat improved absorption (2.3-5%) after 1995; however, these forms were unstable and crystallized and therefore difficult for the body to absorb. The five-lipid carrier, crystal-free CoQ10 in Natural Medicine Formulas’ CoQ10 CF50 represents innovation and improvement in CoQ10 delivery and bioavailability.*

Directions
Take one softgel one to two times daily, or as directed by your healthcare practitioner. Optimal results may be achieved by consuming with meals that contain fat.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Does Not Contain
Wheat, gluten, corn, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

References
1. Morris G, Anderson G, Berk M, et al. Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic
Implications. Mol Neurobiol. 2013 Jun 13. [Epub ahead of print] [PMID: 23761046]
2. Higdon J. CoQ10. Linus Pauling Institute. http://lpi.oregonstate.edu/infocenter/othernuts/coq10/. February 2003. Updated March 2012. Accessed July 25, 2013.
3. Pelton R, LaValle JB, Hawkins EB, et al. Drug-Induced Nutrient Depletion Handbook. 2nd ed. Hudson, OH: LexiComp, Inc.; 2001.
4. Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf. 2006;29(8):703-
12. [PMID: 16872244]
5. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch
Neurol. 2004 Jun;61(6):889-92. [PMID: 15210526]
6. Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human
publications. Biofactors. 2003;18(1-4):101-11. Review. [PMID: 14695925]
7. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001 Dec;20(6):591-8. Review. [PMID: 11771674]
8. Potgieter M, Pretorius E, Pepper MS. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev. 2013 Mar;71(3):
180-8. [PMID: 23452285]
9. Zlatohlavek L, Vrablik M, Grauova B, et al. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101. [PMID: 23183519]
10. Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson’s disease. J Neurol Sci. 2012 Jul 15;318(1-2):72-5. [PMID: 22542608]
11. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):641-6. Review. [PMID: 16205466]
12. Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10 treatment in serious heart failure. Biofactors. 1999;9(2-4):285-9. [PMID: 10416042]
13. Fotino AD, Thompson-Paul AM, Bazzano LA. Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. Am J Clin Nutr. 2013 Feb;97(2):268-
75. [PMID: 23221577]
14. Mabuchi H, Nohara A, Kobayashi J, et al. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in
hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Atherosclerosis. 2007 Dec;195(2):e182-89. [PMID: 17681347]
15. Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.
Proc Natl Acad Sci U S A. 1985 Feb;82(3):901-4. [PMID: 3856239]
16. Mortensen SA, Kumar A, Dolliner P, et al. The effect of Coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study.
[ESCARDIO abstract 440]. European Journal of Heart Failure. 2013 15(S1):S20. http://spo.escardio.org/SessionDetails.aspx?eevtid=61&fp=440&doc=abstract#.
UfQgDI2TjSg. Accessed July 25, 2013.
17. European Society of Cardiology. Important new data shows CoQ10 improves survival in heart failure patients.http://www.escardio.org/congresses/hf2013/
congress-to-you/Pages/new-data-CoQ10-improves-survival-heart-failure-patients.aspx. Accessed July 28, 2013.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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